The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics.
作者： Gerald A Higgins , Ari Allyn-Feuer , Samuel Handelman , Wolfgang Sadee , Brian D Athey
DOI: 10.2217/PGS.15.111
关键词: Genome-wide association study 、 Pharmacogenomics 、 Human phenotype 、 Biology 、 Genetics 、 Candidate gene 、 Epigenome 、 Chromosome conformation capture 、 Computational biology 、 Human genome 、 Epigenomics
摘要: The 4D nucleome has the potential to render challenges in neuropsychiatric pharmacogenomics more tractable. epigenome roadmap consortium demonstrated critical role that noncoding regions of human genome play determination phenotype. Chromosome conformation capture methods have revealed organization nucleus, bringing interactions between distant regulatory elements into close spatial proximity a periodic manner. These functional elucidate mechanisms CNS drug response and side effects previously been unrecognized. This perspective assesses recent advances likely reveal novel pharmacodynamic pathways brain, charting future new avenue research, using temporal architecture as its foundation.
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