Early physiological and biological features in three animal models of induced acute lung injury

摘要: Critically ill patients often develop acute lung injury (ALI) in the context of different clinical conditions. We aimed to explore differences early local and systemic features three experimental animal models ALI. Mechanically ventilated male Sprague–Dawley rats were randomized high tidal volume (VT) ventilation (HVT) (n = 8, VT 24 ml/kg), massive brain (MBI) 8 ml/kg) or endotoxemia (LPS) 8 ml/kg). Each group had its own control eight (VT measured arterial blood gases, mean pressure, compliance, inflammatory mediators plasma their expression gelatinase activity lungs after 3 h injury. Despite maintaining relatively normal function without evidence important structural changes, we observed altered responses all models. LPS triggered most robust response HVT lowest proinflammatory response. The higher Il6, Tnf Cxcl2 mRNA than MBI animals. Metalloproteinase activity/expression neutrophilic recruitment MBI. direct remote insult our ALI captured physiological biological that could lead respiratory and/or multiorgan failure.