NKp46 Recognizes the Sigma1 Protein of Reovirus: Implications for Reovirus-Based Cancer Therapy.

摘要: The recent approval of oncolytic virus for therapy melanoma patients has increased the need precise evaluation mechanisms by which viruses affect tumor growth. Here we show that human NK cell-activating receptor NKp46 and orthologous mouse protein NCR1 recognize reovirus sigma1 in a sialic-acid-dependent manner. We identify sites NKp46/NCR1 binding to leads cell activation vitro Finally, demonstrate is essential reovirus-based vivo Collectively, have identified as novel ligand demonstrated needed both clearance infection therapy.IMPORTANCE Reovirus infects much population during childhood, causing mild disease, hence considered be efficiently controlled immune system. also specifically cells, leading death, currently being tested clinical trials cancer therapy. our system controls killing are not well understood. report here natural killer (NK) cells viral named through NKp46. Using several models, importance protection from tumors new provide evidence control infections