Corticotropin-releasing factor-like activity in human placental extracts
作者： Tamotsu Shibasaki , Emi Odagiri , Kazuo Shizume , Nicholas Ling
关键词: Pituitary gland 、 Dose–response relationship 、 Internal medicine 、 Hypothalamus 、 beta-Endorphin 、 Full Term 、 Endocrinology 、 Placental Extracts 、 Biology 、 Bioassay 、 Anterior pituitary
摘要: Corticotropin-releasing factor (C R F)-like activity, which was first found in the hypothalamus, detected extracts of human placentas obtained at full term from spontaneous deliveries. The molecular size placental CRF-like substance is slightly larger than that adrenocorticotropin. In cultures rat anterior pituitary cells, material shows bioactivity similar to partially purified hypothalamic CRF and synthetic ovine C F on release adrenocorticotropin (β-endorphin. Furthermore, activity placenta attenuated by trypsin digestion. Thus may elaborate a CRF.
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