Function for p300 and not CBP in the apoptotic response to DNA damage
作者： Zhi-Min Yuan , Yinyin Huang , Takatoshi Ishiko , Shuji Nakada , Taiju Utsugisawa
关键词: Biology 、 DNA 、 Cell cycle 、 Cell biology 、 DNA damage 、 Immunology 、 Function (biology) 、 Lesion 、 Cell culture 、 Histone acetyltransferase activity 、 Apoptosis
摘要: The cellular response to ionizing radiation (IR) includes the induction of apoptosis. p300/CBP proteins possess histone acetyltransferase activity and function as transcriptional coactivators p53. We have prepared cells deficient in p300 or CBP define roles these DNA damage. present results demonstrate that p300, but not CBP, contributes IR sensitivity cells. also IR-induced apoptosis is impaired p300-, CBP-, These findings indicate functions apoptotic
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