WDR5 Expression Is Prognostic of Breast Cancer Outcome
作者： Xiaofeng Dai , Wenwen Guo , Chunjun Zhan , Xiuxia Liu , Zhonghu Bai
DOI: 10.1371/JOURNAL.PONE.0124964
关键词:
摘要: WDR5 is a core component of the human mixed lineage leukemia-2 complex, which plays central roles in ER positive tumour cells and major driver androgen-dependent prostate cancer cell proliferation. Given similarities between breast cancers, we explore potential prognostic value gene expression on survival. Our findings reveal that over-expression associated with poor clinical outcome three data sets BreastMark. The eQTL analysis reveals 130 trans-eQTL SNPs whose genes mapped statistical significance are significantly patient These together enriched “cellular development, expression, cycle” signallings. Knocking down MCF7 dramatically decreases viability, but does not alter response to doxorubicin. study under long-range regulation involved cycle, anthracycline could be coupled treatments targeting once such regimen available.
paperity.org参考文章(49)
Robert Gentleman, Vincent J Carey, Wolfgang Huber, Rafael A Irizarry, Sandrine Dudoit, Bioinformatics and Computational Biology Solutions Using R and Bioconductor ,(2006)
G. K. Smyth, limma: Linear Models for Microarray Data Springer, New York, NY. pp. 397- 420 ,(2005) , 10.1007/0-387-29362-0_23
Rigen Mo, Sambasiva M. Rao, Yi-Jun Zhu, Identification of the MLL2 Complex as a Coactivator for Estrogen Receptor α Journal of Biological Chemistry. ,vol. 281, pp. 15714- 15720 ,(2006) , 10.1074/JBC.M513245200
Rainer Fagerholm, Barbara Hofstetter, Johanna Tommiska, Kirsimari Aaltonen, Radek Vrtel, Kirsi Syrjäkoski, Anne Kallioniemi, Outi Kilpivaara, Arto Mannermaa, Veli-Matti Kosma, Matti Uusitupa, Matti Eskelinen, Vesa Kataja, Kristiina Aittomäki, Karl von Smitten, Päivi Heikkilä, Jiri Lukas, Kaija Holli, Jirina Bartkova, Carl Blomqvist, Jiri Bartek, Heli Nevanlinna, NAD(P)H:quinone oxidoreductase 1 NQO1 * 2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer Nature Genetics. ,vol. 40, pp. 844- 853 ,(2008) , 10.1038/NG.155
Anna V. Ivshina, Joshy George, Oleg Senko, Benjamin Mow, Thomas C. Putti, Johanna Smeds, Thomas Lindahl, Yudi Pawitan, Per Hall, Hans Nordgren, John E.L. Wong, Edison T. Liu, Jonas Bergh, Vladimir A. Kuznetsov, Lance D. Miller, Genetic Reclassification of Histologic Grade Delineates New Clinical Subtypes of Breast Cancer Cancer Research. ,vol. 66, pp. 10292- 10301 ,(2006) , 10.1158/0008-5472.CAN-05-4414
Jerry Usary, Victor Llaca, Gamze Karaca, Shafaq Presswala, Mehmet Karaca, Xiaping He, Anita Langerød, Rolf Kåresen, Daniel S Oh, Lynn G Dressler, Per E Lønning, Robert L Strausberg, Stephen Chanock, Anne-Lise Børresen-Dale, Charles M Perou, Mutation of GATA3 in human breast tumors Oncogene. ,vol. 23, pp. 7669- 7678 ,(2004) , 10.1038/SJ.ONC.1207966
Linda B. C. Bralten, Nanne K. Kloosterhof, Lonneke A. M. Gravendeel, Andrea Sacchetti, Elza J. Duijm, Johan M. Kros, Martin J. van den Bent, Casper C. Hoogenraad, Peter A. E. Sillevis Smitt, Pim J. French, Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene. Genes, Chromosomes and Cancer. ,vol. 49, pp. 509- 517 ,(2010) , 10.1002/GCC.20760
Brenda Han, Melissa J Fullwood, Mei Hui Liu, You Fu Pan, Jun-Jun Liu, Xu Han, Yusoff Bin Mohamed, Yuriy L Orlov, Stoyan Velkov, Andrea Ho, Poh Huay Mei, Elaine GY Chew, Phillips Yao Hui Huang, Willem-Jan Welboren, Yuyuan Han, Hong Sain Ooi, Pramila N Ariyaratne, Vinsensius B Vega, Yanquan Luo, Peck Yean Tan, Pei Ye Choy, KD Wansa, Bing Zhao, Kar Sian Lim, Shi Chi Leow, Jit Sin Yow, Roy Joseph, Haixia Li, Kartiki V Desai, Jane S Thomsen, Yew Kok Lee, R Karuturi, Thoreau Herve, Guillaume Bourque, Hendrik G Stunnenberg, Xiaoan Ruan, Valere Cacheux-Rataboul, Wing-Kin Sung, Edison T Liu, Chia-Lin Wei, Edwin Cheung, Yijun Ruan, An oestrogen-receptor-α-bound human chromatin interactome Nature. ,vol. 462, pp. 58- 64 ,(2009) , 10.1038/NATURE08497
Ji-Hu Zhang, Thomas D. Y. Chung, Kevin R. Oldenburg, A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Journal of Biomolecular Screening. ,vol. 4, pp. 67- 73 ,(1999) , 10.1177/108705719900400206
Zhi-Min Yuan, Yinyin Huang, Takatoshi Ishiko, Shuji Nakada, Taiju Utsugisawa, Hisashi Shioya, Yukari Utsugisawa, Yang Shi, Ralph Weichselbaum, Donald Kufe, Function for p300 and not CBP in the apoptotic response to DNA damage Oncogene. ,vol. 18, pp. 5714- 5717 ,(1999) , 10.1038/SJ.ONC.1202930