Quadriceps strength predicts mortality in patients with moderate to severe Chronic Obstructive Pulmonary Disease

摘要: Background: Prognosis in chronic obstructive pulmonary disease (COPD) is poorly predicted by indices of air flow obstruction, because other factors that reflect the systemic nature also influence prognosis. Objective: To test hypothesis a reduction quadriceps maximal voluntary contraction force (QMVC) useful predictor mortality patients with COPD. Methods: A questionnaire was sent to primary care physician 184 COPD who had undergone strength measurement over past 5 years. QMVC expressed as percentage patient’s body mass index. The end point measured death or lung transplantation, and median (range) follow-up 38 (1–54) months. Results: Data were obtained for 162 (108 men 54 women) mean (SD) forced expiratory volume 1 s (FEV ) 35.6 (16.2), giving response rate 88%. Transplant-free survival cohort 93.5% at year 87.1% 2 Cox regression models showed risk increased increasing age reducing QMVC. Only (HR 1.72 (95% CI 1.14 2.6); p = 0.01) 0.91 0.83 0.99); p = 0.036) continued be significant predictors when controlled variables multivariate analysis. Conclusion: simple provides more powerful prognostic information on than provided age, index s.