Fungicidal versus fungistatic activity of terbinafine and itraconazole: an in vitro comparison.

摘要: Abstract Background: The ratio of fungicidal to fungistatic activity two new antifungal agents, itraconazole and terbinafine, against the causative organisms in onychomycosis may have clinical relevance. Objective: This study compared terbinafine isolates dermatophytes Candida species causing onychomycosis. Methods: agent was added suspensions dermatophyte conidia hyphal fragments (5 × 10 3 5 4 fungal elements/ml) that had been preincubated allow formation. Cell (1 cells/ml) were not before drug exposure. Macrobroth macrobroth dilution assays used test susceptibility yeasts, respectively. An considered if minimal concentration (MFC) inhibitory (MIC) ≤ > 4. death also visualized by a vital stain. Results: For both MIC for low. MFCs MFC/MIC ratios lower than itraconazole; excellent initiated rapidly (by 7 hours) poor (fungicidal evident until 12 hours). MICs higher dermatophytes, differences between less pronounced. Conclusion: Both inhibit growth dermatophytes. more rapid relevance treatment (J Am Acad Dermatol 1998;38:S37-41.)