30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor.

摘要: The mineralocorticoid receptor (MR) belongs to the steroid hormone family and classically functions as a ligand-dependent transcription factor. It is involved in water-electrolyte homeostasis blood pressure regulation but independent from these effects also furthers inflammation, fibrosis, hypertrophy remodeling cardiovascular tissues. Next genomic effects, aldosterone elicits very rapid actions within minutes that do not require or translation occur only classical MR epithelial target organs like kidney colon nonepithelial tissues heart, vasculature adipose tissue. Most of can be mediated by its crosstalk with different signaling cascades. Near plasma membrane, seems associated caveolin striatin well tyrosine kinases EGFR, PDGFR IGF1R G protein-coupled receptors AT1 GPER1, which then mediate nongenomic effects. GPER1 has been named putative novel MR. There close interaction functional synergism between so lead long-term support actions. Therefore, understanding aldosterone/MR potential relevance for modulating may provide additional targets intervention.