Localizing epileptogenic regions in partial epilepsy using three-dimensional statistical parametric maps of background EEG source spectra.

作者: Kenneth Alper , Manoj Raghavan , Robert Isenhart , Bryant Howard , Werner Doyle

DOI: 10.1016/J.NEUROIMAGE.2007.09.041

关键词: NeuroscienceScalpPsychologyTomographyEpilepsyVoxelLobeIctalNuclear magnetic resonanceElectroencephalographyEpilepsy surgery

摘要: This preliminary study sought to localize epileptogenic regions in patients with partial epilepsy by analysis of interictal EEG activity utilizing variable resolution electromagnetic tomography (VARETA), a three-dimensional quantitative electroencephalographic (QEEG) frequency-domain distributed source modeling technique. The very narrow band (VNB) spectra spanned the frequency range 0.39 Hz 19.1 Hz, steps. These VNB were compared normative data and transformed provide Z-scores for every scalp derivation, spatial distributions probable generators most abnormal values displayed on slices from probabilistic MRI atlas. Each voxel was color-coded represent significance deviation relative age appropriate values. We resulting images localization based invasive intracranial recordings seizure onsets. VARETA image indicated spectral power onset identified monitoring, mainly delta theta (1.5 8.0 Hz). congruent regard hemisphere all 6 cases, lobe 5 cases. In contrast, findings routine agreed monitoring 3 cases 2 results suggest that background models should be investigated further clinical epilepsy.

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