CD22 Is a Recycling Receptor That Can Shuttle Cargo between the Cell Surface and Endosomal Compartments of B Cells

作者: Mary K. O’Reilly , Hua Tian , James C. Paulson

DOI: 10.4049/JIMMUNOL.1003005

关键词: Endocytic cycleReceptorBiologyB-cell receptorCD22SIGLECB cellCell biologyInternalizationEndosome

摘要: CD22 is a member of the sialic acid-binding Ig-like lectin (Siglec) family that known to be regulator B cell signaling. Its cell-specific expression makes it an attractive target for immunotoxin-mediated depletion therapy treatment lymphomas and autoimmune diseases. Although well documented endocytic receptor, believed after internalization, targeted degradation. We show in this study instead constitutively recycled surface. also find glycan ligand-based cargo released from accumulates intracellularly as recycles between surface endosomal compartments. In contrast, Abs do not accumulate but remain bound recycle The results have implications development agents receptor delivery cytotoxic cells.

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