B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention.

作者: H.-W. Huang , C.-H. Chen , C.-H. Lin , C.-H. Wong , K.-I. Lin

DOI: 10.1073/PNAS.1309417110

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摘要: Glycosylation, an important posttranslational modification process, can modulate the structure and function of proteins, but its effect on the properties of plasma cells is largely unknown. In this study, we identified a panel of glycoproteins by click reaction with alkynyl sugar analogs in plasma cells coupled with mass spectrometry analysis. The B-cell maturation antigen (BCMA), an essential membrane protein for maintaining the survival of plasma cells, was identified as a glycoprotein exhibiting complex-type N-glycans at a single …

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