APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.

作者: Yu-Tzu Tai , Chirag Acharya , Gang An , Michele Moschetta , Mike Y. Zhong

DOI: 10.1182/BLOOD-2016-01-691162

关键词: Bone marrowOsteoclastVascular endothelial growth factor ABiologyCytotoxic T cellCell growthCancer researchTransforming growth factorAngiogenesisParacrine signalling

摘要: Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) …

参考文章(75)
ZJ Gu, V Costes, ZY Lu, XG Zhang, V Pitard, JF Moreau, R Bataille, J Wijdenes, JF Rossi, B Klein, Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop Blood. ,vol. 88, pp. 3972- 3986 ,(1996) , 10.1182/BLOOD.V88.10.3972.BLOODJOURNAL88103972
T Matthes, B Manfroi, A Zeller, I Dunand-Sauthier, B Bogen, B Huard, Autocrine amplification of immature myeloid cells by IL-6 in multiple myeloma-infiltrated bone marrow. Leukemia. ,vol. 29, pp. 1882- 1890 ,(2015) , 10.1038/LEU.2015.145
Thanh-Nhan Nguyen-Pham, Sung-Hoon Jung, Manh-Cuong Vo, Huong-Thi Thanh-Tran, Youn-Kyung Lee, Hyun-Ju Lee, Nu-Ri Choi, My-Dung Hoang, Hyeoung-Joon Kim, Je-Jung Lee, Lenalidomide Synergistically Enhances the Effect of Dendritic Cell Vaccination in a Model of Murine Multiple Myeloma. Journal of Immunotherapy. ,vol. 38, pp. 330- 339 ,(2015) , 10.1097/CJI.0000000000000097
Henk M. Lokhorst, Torben Plesner, Jacob P. Laubach, Hareth Nahi, Peter Gimsing, Markus Hansson, Monique C. Minnema, Ulrik Lassen, Jakub Krejcik, Antonio Palumbo, Niels W.C.J. van de Donk, Tahamtan Ahmadi, Imran Khan, Clarissa M. Uhlar, Jianping Wang, A. Kate Sasser, Nedjad Losic, Steen Lisby, Linda Basse, Nikolai Brun, Paul G. Richardson, Targeting CD38 with daratumumab monotherapy in multiple myeloma The New England Journal of Medicine. ,vol. 373, pp. 1207- 1219 ,(2015) , 10.1056/NEJMOA1506348
Xiong Lei, Yun-feng Li, Guo-dong Chen, Di-peng Ou, Xiao-xin Qiu, Chao-hui Zuo, Lian-Yue Yang, Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma Oncotarget. ,vol. 6, pp. 40622- 40641 ,(2015) , 10.18632/ONCOTARGET.5872
H Jiang, C Acharya, G An, M Zhong, X Feng, L Wang, N Dasilva, Z Song, G Yang, F Adrian, L Qiu, P Richardson, N C Munshi, Y-T Tai, K C Anderson, SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide. Leukemia. ,vol. 30, pp. 399- 408 ,(2016) , 10.1038/LEU.2015.240
Güllü Görgün, Mehmet K. Samur, Kristen B. Cowens, Steven Paula, Giada Bianchi, Julie E. Anderson, Randie E. White, Ahaana Singh, Hiroto Ohguchi, Rikio Suzuki, Shohei Kikuchi, Takeshi Harada, Teru Hideshima, Yu-Tzu Tai, Jacob P. Laubach, Noopur Raje, Florence Magrangeas, Stephane Minvielle, Herve Avet-Loiseau, Nikhil C. Munshi, David M. Dorfman, Paul G. Richardson, Kenneth C. Anderson, Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma Clinical Cancer Research. ,vol. 21, pp. 4607- 4618 ,(2015) , 10.1158/1078-0432.CCR-15-0200
Fiona C. Kimberley, Michael Hahne, Jan Paul Medema, "APRIL hath put a spring of youth in everything": Relevance of APRIL for survival. Journal of Cellular Physiology. ,vol. 218, pp. 1- 8 ,(2009) , 10.1002/JCP.21561
Christina M. Annunziata, R. Eric Davis, Yulia Demchenko, William Bellamy, Ana Gabrea, Fenghuang Zhan, Georg Lenz, Ichiro Hanamura, George Wright, Wenming Xiao, Sandeep Dave, Elaine M. Hurt, Bruce Tan, Hong Zhao, Owen Stephens, Madhumita Santra, David R. Williams, Lenny Dang, Bart Barlogie, John D. Shaughnessy, W. Michael Kuehl, Louis M. Staudt, Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma Cancer Cell. ,vol. 12, pp. 115- 130 ,(2007) , 10.1016/J.CCR.2007.07.004
Longchuan Bai, David C. Smith, Shaomeng Wang, Small-molecule SMAC mimetics as new cancer therapeutics. Pharmacology & Therapeutics. ,vol. 144, pp. 82- 95 ,(2014) , 10.1016/J.PHARMTHERA.2014.05.007