NF-κB dysregulation in multiple myeloma.
作者： Geoffrey M. Matthews , Ricardo de Matos Simoes , Eugen Dhimolea , Michal Sheffer , Sara Gandolfi
DOI: 10.1016/J.SEMCANCER.2016.08.005
关键词: Proteasome 、 Immunology 、 Cancer research 、 Transcription factor 、 Multiple myeloma 、 Signal transduction 、 Stromal cell 、 Biology 、 Tumor microenvironment 、 NFKB1 、 NF-κB
摘要: The nuclear factor-κB (NF-κB) transcription factor family plays critical roles in the pathophysiology of hematologic neoplasias, including multiple myeloma. current review examines that this system myeloma cells and nonmalignant accessory local microenvironment; as well evidence indicating a large proportion patients harbor genomic lesions which perturb diverse genes regulating activity NF-κB. This article also discusses therapeutic targeting NF-κB pathway using proteasome inhibitors, pharmacological class has become cornerstone management myeloma; reviews some future challenges opportunities for NF-κB-related research
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