Lenalidomide Synergistically Enhances the Effect of Dendritic Cell Vaccination in a Model of Murine Multiple Myeloma.

摘要: We investigated the efficacy of lenalidomide (LEN) in combination with dendritic cell (DC) vaccination MOPC-315 murine myeloma model. After tumor growth, LEN was injected intraperitoneally for 4 consecutive days DC vaccination. The and efficiently inhibited growth compared single agents alone. A cytotoxic assay revealed that anticancer effects plus involved not only generation antigen-specific T lymphocytes but also NK cells. Vaccinated mice had reduced numbers suppressor cells, including both myeloid-derived cells regulatory spleen. proportions CD4+ CD8+ increased spleen, a Th1 cytokine (interferon-γ) rather than Th2 (interleukin-10) synthesized response to antigens. enhanced innate immune by modulating function. In addition, production levels angiogenesis-inducing factors tumor-bearing mice. Together, these results suggest may synergistically enhance immunity model, inhibiting immunosuppressor stimulating effector as well effectively polarizing Th1/Th2 balance favor Th1-specific response.