B cell maturation antigen (BCMA)-based immunotherapy for multiple myeloma

Jooeun Bae, Yu‐Tzu Tai, Kenneth C. Anderson, Nikhil C. Munshi, Novel epitope evoking CD138 antigen-specific cytotoxic T lymphocytes targeting multiple myeloma and other plasma cell disorders British Journal of Haematology. ,vol. 155, pp. 349- 361 ,(2011) , 10.1111/J.1365-2141.2011.08850.X

Micah J. Benson, Stacey R. Dillon, Emanuela Castigli, Raif S. Geha, Shengli Xu, Kong-Peng Lam, Randolph J. Noelle, Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. Journal of Immunology. ,vol. 180, pp. 3655- 3659 ,(2008) , 10.4049/JIMMUNOL.180.6.3655

Sarah A. Laurent, Franziska S. Hoffmann, Peer-Hendrik Kuhn, Qingyu Cheng, Yuanyuan Chu, Marc Schmidt-Supprian, Stefanie M. Hauck, Elisabeth Schuh, Markus Krumbholz, Heike Rübsamen, Johanna Wanngren, Mohsen Khademi, Tomas Olsson, Tobias Alexander, Falk Hiepe, Hans-Walter Pfister, Frank Weber, Dieter Jenne, Hartmut Wekerle, Reinhard Hohlfeld, Stefan F. Lichtenthaler, Edgar Meinl, γ-secretase directly sheds the survival receptor BCMA from plasma cells Nature Communications. ,vol. 6, pp. 7333- 7333 ,(2015) , 10.1038/NCOMMS8333

Henk M. Lokhorst, Torben Plesner, Jacob P. Laubach, Hareth Nahi, Peter Gimsing, Markus Hansson, Monique C. Minnema, Ulrik Lassen, Jakub Krejcik, Antonio Palumbo, Niels W.C.J. van de Donk, Tahamtan Ahmadi, Imran Khan, Clarissa M. Uhlar, Jianping Wang, A. Kate Sasser, Nedjad Losic, Steen Lisby, Linda Basse, Nikolai Brun, Paul G. Richardson, Targeting CD38 with daratumumab monotherapy in multiple myeloma The New England Journal of Medicine. ,vol. 373, pp. 1207- 1219 ,(2015) , 10.1056/NEJMOA1506348

H Jiang, C Acharya, G An, M Zhong, X Feng, L Wang, N Dasilva, Z Song, G Yang, F Adrian, L Qiu, P Richardson, N C Munshi, Y-T Tai, K C Anderson, SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide. Leukemia. ,vol. 30, pp. 399- 408 ,(2016) , 10.1038/LEU.2015.240

Michel Sadelain, CAR therapy: the CD19 paradigm Journal of Clinical Investigation. ,vol. 125, pp. 3392- 3400 ,(2015) , 10.1172/JCI80010

Thomas Matthes, Isabelle Dunand-Sauthier, Marie-Laure Santiago-Raber, Karl-Heinz Krause, Olivier Donze, Jakob Passweg, Tomas McKee, Bertrand Huard, Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow Blood. ,vol. 118, pp. 1838- 1844 ,(2011) , 10.1182/BLOOD-2011-01-332940

H.-W. Huang, C.-H. Chen, C.-H. Lin, C.-H. Wong, K.-I. Lin, B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 10928- 10933 ,(2013) , 10.1073/PNAS.1309417110

Arthur L. Shaffer, N. C. Tolga Emre, Laurence Lamy, Vu N. Ngo, George Wright, Wenming Xiao, John Powell, Sandeep Dave, Xin Yu, Hong Zhao, Yuxin Zeng, Bangzheng Chen, Joshua Epstein, Louis M. Staudt, IRF4 addiction in multiple myeloma. Nature. ,vol. 454, pp. 226- 231 ,(2008) , 10.1038/NATURE07064

Yu-Tzu Tai, Patrick A. Mayes, Chirag Acharya, Mike Y. Zhong, Michele Cea, Antonia Cagnetta, Jenny Craigen, John Yates, Louise Gliddon, William Fieles, Bao Hoang, James Tunstead, Amanda L. Christie, Andrew L. Kung, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson, Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma. Blood. ,vol. 123, pp. 3128- 3138 ,(2014) , 10.1182/BLOOD-2013-10-535088