Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation

摘要: BAFF plays a central role in B-lineage cell biology; however, the regulation of BAFF-binding receptor (BBR) expression during B activation and differentiation is not completely understood. In this study, we provide comprehensive ex vivo analysis BBRs human cells at various stages maturation, as well describe events that drive regulate expression. Our data reveal ranging from naive to plasma (PCs), excluding bone marrow PCs, express BAFF-R uniformly. contrast, only tonsillar memory (MB) both tonsil tissues, BCMA. Furthermore, show TACI expressed by MB subpopulation activated CD27 neg cells. regard, demonstrate inducible early upon independent turnover. addition, found requires ERK1/2 pathway, since its was blocked ERK1/2-specific inhibitors. Expression maturation Ag (BCMA) also highly regulated BCMA acquired manner accompanied loss This inverse coincides with into Ig-secreting (ISC), blocking inhibited induction BAFF-R. Collectively, our suggest BBR profile may serve footprint history stage normal