Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia

摘要: Recent reports suggest that the expression of germline (GL) Ig variable region heavy-chain genes (VH) is a negative prognostic factor for B-cell chronic lymphocytic leukaemia (B-CLL) patients and CLL CD38 may be surrogate marker VH gene status. Currently, however, usefulness this controversial. Therefore, our goal was to study ability act as somatic mutation (SM), identify differences in overall survival (OS), progression-free (PFS) response B-CLL based on these two markers. We first assessed relationship between status 131 patients, including 66 enrolled three North Central Cancer Treatment Group Trials. Although mean percentages CD38+ clonal B cells were significantly higher classified GL versus SM, not reliable SM. Overall, exhibited shorter OS PFS times than SM patients. Despite inability predict status, with ≥ 30% did have < 30% cells. Thus, straightforward. Nevertheless, analysis co-operative group clinical trial setting suggests both markers alone or combination usefulness. These data strongly encourage biological they relate disease heterogeneity B-CLL.