Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.
作者： Stuart M. Lichtman , Philip Schulman , Vincent P. Vinciguerra , Kanti R. Rai , Manlio Ferrarini
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摘要: Cellular immunophenotypic studies were performed on a cohort of randomly selected IgM(+) B-chronic lymphocytic leukemia (B-CLL) cases for which Ig V(H) and V(L) gene sequences available. The categorized based V mutation status CD38 expression analyzed treatment history survival. B-CLL could be divided into 2 groups. Those patients with unmutated genes displayed higher percentages CD38(+) cells (>/=30%) than those mutated that had lower ( /=30% groups responded poorly to continuous multiregimen chemotherapy (including fludarabine) shorter In contrast, the groups, marked male predominance was found. Thus, appear accurate predictors clinical outcome in patients. These parameters, especially can conveniently most laboratories, should valuable adjuncts present staging systems predicting course individual cases. Future evaluations new therapeutic strategies drugs take account different natural histories these manners.
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