Ancillary Studies on Neoplastic Cytologic Specimens

摘要: Fine-needle aspiration (FNA) cytology is a safe, rapid, and cost-effective diagnostic procedure that widely used for evaluating lesions at virtually any site in the human body. In order to provide valuable information enables oncologists make optimal therapeutic decisions, use of ancillary studies as adjuncts often required. Ancillary allow us document lesion be neoplastic or nonneoplastic, benign malignant, primary metastatic malignancy, possible origin neoplasm. addition, some tests may prognostic predictive assess eligibility patient certain targeted therapies. Immunocytochemistry most commonly method on specimens; flow cytometric immunophenotyping very useful adjunct diagnosis hematopoietic neoplasms. Recently, advances molecular biology biomedical research have had major impact practice pathology including cytology. As result, cytogenetic been increasingly applied daily practice. It noteworthy test results should evaluated concert with cytologic features, clinical radiologic findings avoid erroneous interpretation. This chapter outlines utility immunocytochemistry, cytometric, cytogenetic, their indications, sample requirements, reliability limitations.