Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola
作者： Hye Jin Jung , Hyang Burm Lee , Chi-Hwan Lim , Chang-Jin Kim , Ho Jeong Kwon
DOI: 10.1016/S0968-0896(03)00523-6
关键词: Cytotoxicity 、 In vitro 、 Cell culture 、 Pharmacology 、 Endothelial stem cell 、 Chemistry 、 Tube formation 、 Neovascularization 、 Biochemistry 、 Angiogenesis 、 Angiogenesis inhibitor 、 Organic chemistry 、 Clinical biochemistry 、 Molecular medicine 、 Molecular biology 、 Drug discovery 、 Pharmaceutical Science
摘要: Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis bovine aortic endothelial cells (BAECs) such bFGF-induced tube formation and invasion at concentration (1 microg/mL) without cytotoxicity. Notably, exhibited more inhibition activity for growth BAECs than that normal cancer cell lines investigated this study. These results demonstrate is new agent can be developed therapeutic angiogenesis-related diseases.
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