A Population Genetic Study of Middle Eastern Populations Using DYS 458 Microvariants and Cohen Modal Haplotypes

摘要: A POPULATION STUDY OF MIDDLE EASTERN POPULATIONs USING DYS458 MICROVARIANTS AND COHEN MODAL SHORT TANDEM REPEATS Enass Tinah Department of Microbiology and Molecular Biology Master Science comprehensive population study in the Middle East was conducted using different genetic markers order to establish a wider profile Eastern populations. The main goal this analyze DNA from samples collected locations, produce motifs patterns that could be used identify distinguish target This information will allow us ancestry these populations, their interactions through time space, effects have on populations’ structure. We around 1300 individual populations ranging Oman southern Arabia, West Bank Gaza Palestine. Our can divided into two primary groups: 320 come Oman; region is important because its geographical proximity Yemen which perceived as historical area where Arabs originated 800 came Palestine, central connects Asia Africa passageway between continents history. genealogy charts were provided by participants, while lack charts. iv extracted samples, amplified PCR technology, sequenced genotyped non-recombining markers. Short Tandem Repeats (STR) screened samples. specific STR marker, DYS458, exhibited an alternative allele at repeat number 18 2 base pair shift identified microvariant 18.2. showed unusually high frequency When 18.2 haplotype combined with Modal Cohen Haplotype (MCH) motifs, we able infer some characteristics about our combination results analyses construct snapshot East, NETWORK software relationship within Oman, located Southern areas North Arabia (Jordan, Syria, Palestine), also known Levant.