Divergent human Y-chromosome microsatellite evolution rates.

摘要: In this work, we analyze several characteristics influencing the low variability of microsatellite DYS19 in major founder Amerindian Y chromosome lineage containing point mutation DYS199-T. Variation was compared with that five other Y-linked tetranucleotide repeat loci (DYS389A, DYS389B, DYS390, DYS391, and DYS393) DYS199-T lineage. All microsatellites showed significantly higher levels than as measured by gene diversity number variance. Moreover, had previously shown high Brazilians populations worldwide. Thus, slow evolution seems to be both locus allele specific. To understand evolutionary rate, were according their mapping on also basis structural aspects such base composition motif flanking regions degree perfection size (repeat number) variable blocks. The only observed difference might related is its small average repeats, a value expected closer These data derived lineages. Tat-C displayed lower correlated number, while DYS234-G lineage, found associated larger number. This approach reveals lineages defined slowly evolving markers, mutations, can greatly influenced (number repeats block) each locus. Thus lineage-dating methods using variation should practiced great care.