Mix and match: building manifold binding sites.

作者: Hennie R. Hoogenboom

DOI: 10.1038/NBT0297-125

关键词: Manifold (fluid mechanics)CombinatoricsBinding sitePhysics

摘要:

参考文章(10)
Dario Neri, Monica Momo, Terence Prospero, Greg Winter, High-affinity antigen binding by chelating recombinant antibodies (CRAbs). Journal of Molecular Biology. ,vol. 246, pp. 367- 373 ,(1995) , 10.1006/JMBI.1994.0091
P. Holliger, T. Prospero, G. Winter, "Diabodies": small bivalent and bispecific antibody fragments Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 6444- 6448 ,(1993) , 10.1073/PNAS.90.14.6444
Taizo Nitta, Hideo Yagita, Ko Okumura, Kiyoshi Sato, Shozo Ishii, Preliminary trial of specific targeting therapy against malignant glioma The Lancet. ,vol. 335, pp. 368- 371 ,(1990) , 10.1016/0140-6736(90)90205-J
Brian T. McGuinness, Gerald Walter, Kevin FitzGerald, Paula Schuler, Walt Mahoney, Alexander R. Duncan, Hennie R. Hoogenboom, Phage diabody repertoires for selection of large numbers of bispecific antibody fragments Nature Biotechnology. ,vol. 14, pp. 1149- 1154 ,(1996) , 10.1038/NBT0996-1149
Peter Pack, Kristian MÜller, Ralph Zahn, Andreas Plückthun, Tetravalent miniantibodies with high avidity assembling in Escherichia coli. Journal of Molecular Biology. ,vol. 246, pp. 28- 34 ,(1995) , 10.1006/JMBI.1994.0062
M. Josefina Coloma, Sherie L. Morrison, Design and production of novel tetravalent bispecific antibodies Nature Biotechnology. ,vol. 15, pp. 159- 163 ,(1997) , 10.1038/NBT0297-159
C Renner, W Jung, U Sahin, R Denfeld, C Pohl, L Trumper, F Hartmann, V Diehl, R van Lier, M Pfreundschuh, Cure of xenografted human tumors by bispecific monoclonal antibodies and human T cells Science. ,vol. 264, pp. 833- 835 ,(1994) , 10.1126/SCIENCE.8171337
Philipp Holliger, Greg Winter, Engineering bispecific antibodies. Current Opinion in Biotechnology. ,vol. 4, pp. 446- 449 ,(1993) , 10.1016/0958-1669(93)90010-T