Modulation of platelet adhesion based on the surface-exposed beta-switch loop of platelet glycoprotein IB-alpha
作者： Eric Geert Huizinga , Piet Gros , Roland Antonius Paulus Romijn , Marion Eveline Schiphorst , Philip Gerrit de Groot
DOI:
关键词:
摘要: The invention relates to the adhesion of platelet GpIba strand b3 domain A1 von Willebrand factor (vWF), said comprising amino acid residues at position 560-566 and/or a functional part or equivalent thereof, GpIbalpha, GpIbalpha region an sequence corresponding beta-switch loop 227-242 thereof. provides method interfere with blood platelets vWF modulating adhesion. further proteinaceous compounds, antibodies, medicaments and pharmaceutical compositions that end. also means methods increase by topical application compound increasing
lens.org
wipo.int参考文章(79)
Paul J Murdock, Barry J Woodhams, Kathy B Matthews, K John Pasi, Alison H Goodall, von Willebrand factor activity detected in a monoclonal antibody-based ELISA: an alternative to the ristocetin cofactor platelet agglutination assay for diagnostic use. Thrombosis and Haemostasis. ,vol. 78, pp. 1272- 1277 ,(1997) , 10.1055/S-0038-1657727
Edward L. Tobinick, TNF modulators for treating neurological disorders associated with viral infection ,(2000)
Yaakov Scheinert, Michael Peled, Theodor-Morel Fishler, Leonard M. Shorr, Use of monomeric pentabromobenzyl monoacrylate as flame retardant ,(1989)
Zaverio M. Ruggeri, Kottayil I. Varughese, Reha Celikel, von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule Nature Structural & Molecular Biology. ,vol. 7, pp. 881- 884 ,(2000) , 10.1038/79639
W.D. Mallender, E.W. Voss, Construction, expression, and activity of a bivalent bispecific single-chain antibody. Journal of Biological Chemistry. ,vol. 269, pp. 199- 206 ,(1994) , 10.1016/S0021-9258(17)42334-9
Robert I. Handin, Huabing Yuan, Anne McLeod, Conformation-specific anti-von Willebrand factor antibodies ,(1999)
Karen Silence, Paul P. M. P. Van Bergen En Henegouwen, Mark Vaeck, Method of administering therapeutic polypeptides, and polypeptides therefor ,(2003)
Michael C Berndt, Yang Shen, Sacha M Dopheide, Elizabeth E Gardiner, Robert K Andrews, None, The Vascular Biology of the Glycoprotein Ib-IX-V Complex Thrombosis and Haemostasis. ,vol. 86, pp. 178- 188 ,(2001) , 10.1055/S-0037-1616216
Anthony Henniker, David Facey, Mark Hertzberg, Emmanuel Favaloro, Discrimination of von Willebrands disease (VWD) subtypes: direct comparison of von Willebrand factor:collagen binding assay (VWF:CBA) with monoclonal antibody (MAB) based VWF-capture systems. Thrombosis and Haemostasis. ,vol. 84, pp. 541- 547 ,(2000) , 10.1055/S-0037-1614064
Alicia J. Schade, José A. López, Gabriel M. Romo, Jing Fei Dong, Shan Gao, Larry V. McIntire, Robert K. Andrews, Novel Gain-of-function Mutations of Platelet Glycoprotein Ibα by Valine Mutagenesis in the Cys209–Cys248 Disulfide Loop FUNCTIONAL ANALYSIS UNDER STATIC AND DYNAMIC CONDITIONS Journal of Biological Chemistry. ,vol. 275, pp. 27663- 27670 ,(2000) , 10.1074/JBC.M909952199