Process for the production of indole derivatives

作者: David Charles Waite

DOI:

关键词: ChemistryIndole testPalladiumOrganic chemistryCatalysisSolvent

摘要: The invention provides a process for the production of compound formula (I), which comprises reacting (II) with (III), in presence strong base and palladium(0) catalyst, at an elevated temperature, solvent does not adversely affect reaction. Compounds (I) may be further processed to compounds (V), are useful treatment inter alia migraine.

参考文章(3)
Keith Dean Combrink, Edward H. Ruediger, Joseph P. Yevich, Andrew Williams, Bradley Clyde Pearce, Frank D. Yocca, David W. Smith, Ronald J. Mattson, Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines ,(1992)
David Edmund Bays, Peter Charles North, John Bradshaw, Wasyl Feniuk, Indole derivatives, their use as medicines and pharmaceutical compositions containing them ,(1992)
Alexander William Oxford, Derive d'indole ,(1985)