An introduction to induced pluripotent stem cells.
作者： Joanna Hanley , Ghasem Rastegarlari , Amit C. Nathwani
DOI: 10.1111/J.1365-2141.2010.08296.X
关键词: Induced pluripotent stem cell 、 Cell biology 、 Embryonic stem cell 、 Adult stem cell 、 Embryoid body 、 Biology 、 Induced stem cells 、 Stem cell 、 KOSR 、 Cell potency 、 Immunology
摘要: Recent landmark studies show that it is now possible to convert somatic cells, such as skin fibroblasts and B lymphocytes, into pluripotent stem cells closely resemble embryonic cells. These induced (iPS) can be generated without using human embryos or oocytes, thus bypassing some of the ethical issues have limited use stems (hES) Additionally, they derived from patient treated, thereby overcoming problems immunological rejection associated with allogeneic hES cell progenitors. Whilst these patient-specific iPS great clinical potential, their immediate utility likely in drug screening for understanding disease process. This review discusses promise well challenges clinic.
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