Chronic Wasting Disease

摘要: Chronic wasting disease (CWD) is a prion of free-ranging and farmed ungulates (deer, elk, moose) in North America South Korea. First described by the late E.S. Williams colleagues northern Colorado southern Wyoming 1970s, CWD has increased tremendously both numerical geographical distribution, reaching prevalence rates as high 50% >90% captive deer herds certain areas USA Canada. certainly most contagious infection, with significant horizontal transmission infectious prions by, e.g., urine, feces, saliva. Dissemination persistence infectivity environment combined appearance wild-living migrating animals make presently uncontrollable, pose extreme challenges to wild-life management. Whereas extremely transmissible among cervids, its trans-species seems be restricted, although possible involvement rodent carnivore species environmental not been fully evaluated. Whether or zoonotic potential had Bovine spongiform encephalopathy (BSE) yet answered. Of note, variant Creutzfeldt–Jakob (vCJD) was only detected because clinical presentation age patients were significantly different from classical CJD. Along further understanding molecular biology pathology CWD, transmissibility restrictions development methods for preclinical diagnosis intervention will crucial effective containment this highly disease.