Glutathione-S-transferase pi (GSTP1) codon 105 polymorphism is not associated with oxaliplatin efficacy or toxicity in advanced colorectal cancer patients.
作者： Dina M. Kweekel , Hans Gelderblom , Ninja F. Antonini , Tahar Van der Straaten , Johan W.R. Nortier
DOI: 10.1016/J.EJCA.2008.10.015
关键词: Capecitabine 、 Immunology 、 Genotype 、 Oxaliplatin 、 Glutathione S-Transferase pi 、 Cancer 、 Colorectal cancer 、 GSTP1 、 Internal medicine 、 Medicine 、 Toxicity 、 Gastroenterology
摘要: Abstract Purpose Oxaliplatin is detoxified by conjugation to glutathione via the enzyme Glutathione- S -transferase pi (GSTP1). The aim of this study investigate association GSTP1 Ile105Val genetic polymorphism with oxaliplatin efficacy and toxicity in advanced colorectal cancer (ACC) patients. Experimental design A total 91 ACC patients received capecitabine (CAPOX) as a part multicentre phase-III Dutch Colorectal Cancer Group. Tumour response was evaluated according RECIST, graded using CTC, determined pyrosequencing. Results Overall survival after CAPOX similar for Ile/Ile (11.5 mo), Ile/Val (11.6 mo) Val/Val (12.6 genotypes ( p =0.602). Likewise, there were no statistically significant differences progression-free =0.252). grades 3–4 not related genotype =0.313). There any grade or neurotoxicity amongst who ⩾500mg/m 2 -values 0.376 0.772, respectively). Conclusions results indicate that predictive overall treated CAPOX. Moreover, receiving associated genotype.
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