Phase I trial of 5-day continuous venous infusion of oxaliplatin at circadian rhythm-modulated rate compared with constant rate.

作者: Jean-Pierre Caussanel , Francis Lévi , Silvano Brienza , Jean-Louis Misset , Moshe Itzhaki

DOI: 10.1093/JNCI/82.12.1046

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摘要: … of higher doses at 16 hours than at 4 hours in patients with cancer. We hypothesized that the continuous venous infusion of … would deliver a higher dose to the patient if the drug were …

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