Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. A comparison with IL-4-mediated signaling.

摘要: Resting tonsillar B lymphocytes were shown to enlarge and become more buoyant when exposed either IL-4 or a mAb (G28-5) the 50-kDa CDw40 Ag. A striking feature of activation through was promotion strong homotypic adhesions which did not occur in populations cultured with IL-4. Whereas antibody down-regulated its target Ag, an increased expression accompanied stimulation. Similarly, only IL-4, antibody, able induce appearance CD23 on resting cell surface. Functionally, major consequence ligating cells that they remained alert subsequent mitogenic signaling--cells incubated developed same sluggish response as noted control cultures. Together, provoked small, but significant, level DNA synthesis enhanced dramatically by inclusion low m.w. growth factor. This latter agent had no discernible direct effect lymphocytes. The different pathways have been observed for triggering are discussed.