Liver fibrosis progression at autopsy in injecting drug users infected by hepatitis C: A longitudinal long-term cohort study
作者： Knut Boe Kielland , Gerd Jorunn Møller Delaveris , Sidsel Rogde , Tor Jacob Eide , Ellen J. Amundsen
DOI: 10.1016/J.JHEP.2013.09.022
关键词: Immunology 、 Internal medicine 、 Hepatitis C virus 、 Hepatitis C 、 Hepatocellular carcinoma 、 Cirrhosis 、 HBsAg 、 Fibrosis 、 Medicine 、 Cohort study 、 Cohort
摘要: Background & Aims There is a paucity of unbiased data on the natural history hepatitis C virus (HCV) infection in injecting drug users (IDUs). The purpose this study was to assess risk developing advanced fibrosis associated with chronic (CHC) among (IDUs) who underwent an autopsy. Methods A longitudinal cohort design applied, which stage liver anti-HCV positive IDUs or without HCV assessed tissue from autopsies performed up 35years after exposure. originated 864 consecutively admitted for abuse treatment 1970–1984. Stored sera, mostly drawn at time admission treatment, were available 635 subjects. 220 out 523 subjects had died before 2009. Liver 102/220 subjects, 61 RNA positive. sections classified according METAVIR scores fibrosis. Two pathologists, both blinded serologic results, scored tissue. Results Among 16.4% (10/61) septal (F3) cirrhosis (F4) compared 2.4% (1/41) anti positive/HCV negative ( p =0.026). Of 18 autopsied 25years exposure 35% (6/17) F3–F4. Conclusions chronically infected by HCV, 1/3 developed more
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