Efficacy of sofosbuvir-based therapies in HIV/HCV infected patients and persons who inject drugs

摘要: Abstract In the era of Directly Acting anti HCV Antivirals treatment hepatitis C is successful in majority persons treated. However, with HIV or who inject drugs remains challenging because special issues: drug–drug interactions antiretroviral, psychiatric and drug substitution therapies, adherence, impact on disease course risk bacterial infections. Sofosbuvir induced sustained virologic response 91% 23 HIV/HCV coinfected treated combination ribavirin pegylated interferon, 83% 497 all 50 patients infected GT1 ledipasvir ribavirin. The rates efficacy HCV–HIV were almost same as those observed monoinfected suggesting that sofosbuvir not reduced by coinfection. There are no data injection users. pangenotypic activity, high barrier to resistance, modest potential for makes a reference these two populations.