Control of Nematode Parasites with Agents Acting on Neuro-Musculature Systems: Lessons for Neuropeptide Ligand Discovery

摘要: There are a number of reasons why the development novel anthelmintics is very necessary. In domestic animals, parasites cause serious loss production and welfare concern. The control these requires changes in management practices to reduce spread infection use therapeutic agents treat affected animals. vaccines against desirable but their so far has been limited. One notable exception vaccination calves by Dictyocaulus viviparous (lungworm) which proved be effective.2 total market for anti-parasitic (both ecto- endo-parasites) excess billion US dollars. humans there problems morbidity mortality associated with parasite infections. 1.6 People throughout world infected ascariasis (Fig. 1A) and/or hookworm. Approximately one-third world’s population suffering from effects intestinal nematode parasites, causing low growth-rates infants, ill-thrift, diarrhea 2% cases, life. Despite huge individuals, drugs not big enough foster because most infestations that occur undeveloped countries lack ability pay drugs. major economic motivator then, animal anthelmintics.