Present-day anthelmintics and perspectives on future new targets.

摘要: In absence of vaccines for the majority helminths, chemotherapy is still mainstay controlling human helminthiases. However, a limited number drugs are available in market to combat parasitic helminths human. Besides, development and spread drug resistance have declined use most currently anthelmintics. Clearly, availability new anthelmintic agents will be essential next few years. More research into mechanisms actions their targets eminent discovery novel agents. Recent techniques mostly rely on mechanism-based screening compounds heterologously expressed bacterial, mammalian or yeast cells. Although this usually successful approach, it money- time-consuming; meanwhile, pharmaceutical companies prefer tested target that chosen based basic research. The nervous system site action several chemotherapeutics including pesticides antinematode drugs; accordingly, continues promising target. advances exploring helminths' system, neurotransmitters receptors paved way potential targeting its components.