Spotlight on the in vitro effect of artemisinin-naphthoquine phosphate on Schistosoma mansoni and its snail host Biomphalaria alexandrina

摘要: Abstract Malaria and schistosomiasis are the two most important parasitic diseases in tropics sub-tropics with geographic overlap. Efforts have been made for developing new schistosomicidal drugs, or testing existing drugs originally used non-related diseases. The antimalarial artemisinin–naphthoquine phosphate combination (CO-ArNp) was recently reported to be a promising novel antischistosomal therapy potent vivo activity against Schistosoma mansoni. In this work, we report vitro dose- time-response effect of CO-ArNp Egyptian strain S. mansoni, its snail host, Biomphalaria alexandrina. Incubation adult mansoni at 40 20 μg/ml 48 72 h killed all worms. Exposure miracidia cercariae molluscicidal LC50 (16.8 μg/ml) resulted 100% mortality free larval stages within 90 15 min, respectively. Moreover, incubation B. alexandrina snails drug 40 μg/ml 24 h. Scanning electron microscope revealed marked morphological tegumental alterations on different parasite soft tissue. Our study highlights effects phosphate. No doubt more studies needed clarify potential value control schistosomiasis.