"I-MOVE" towards monitoring seasonal and pandemic influenza vaccine effectiveness: lessons learnt from a pilot multi-centric case-control study in Europe, 2008-9.

摘要: Within I-MOVE (European programme to monitor seasonal and pandemic influenza vaccine effectiveness (IVE)) five countries conducted IVE pilot case-control studies in 2008-9. One hundred sixty sentinel general practitioners (GP) swabbed all elderly consulting for influenza-like illness (ILI). Influenza confirmed cases were compared negative controls. We a pooled analysis obtain summary the age group of >or=65 years. measured each study assessed heterogeneity between qualitatively using I2 index. used one-stage model with as fixed effect. adjusted estimates age-group, sex, chronic diseases, smoking, functional status, previous vaccinations hospitalisations. The included 138 189 test-negative There was no statistical (I2=0) but ILI case definition, hospitalisations status slightly different. 59.1% (95% CI: 15.3-80.3%). 65.4% 15.6-85.8%) 65-74, 59.6% -72.6 -90.6%) >or=75 56.4% -0.2-81.3%) A(H3). Pooled is feasible among European studies. variables definitions need further standardisation. Larger sample sizes are needed achieve greater precision subgroup analysis. For 2009-10, will extend early groups targeted H1N1 vaccination.