Mucosal HIV Infection: A Paradigm for Dysregulation of the Mucosal Immune System

摘要: Publisher Summary The gut-associated lymphoid tissue (GALT) comprises an enormous amount of immune cells and the rectal mucosa is most likely portal entry human immunodeficiency virus (HIV) in major risk group for HIV infection industrialized countries, namely, homosexual bisexual men. may enter host by direct inoculation blood stream or close contact with mucosal surfaces. In peripheral infects helper/inducer subset T lymphocytes high-affinity binding its envelope glycoprotein, gpl20, to CD4 molecule. receptor present high density on helper lymphocyte subset, a lower many monocyte-macrophage lineage, certain other cell types. This chapter presents data load comparison blood. Then, consequences T-cell response humoral are discussed. Finally, presented which indicate that intestinal structure function disturbed HIV-infected patients.