The immunopathogenesis of HIV infection.

摘要: Publisher Summary This chapter reviews the state of knowledge concerning structure and function HIV genome, virus cell tropism, cytotoxic noncytotoxic effects on both immune system central nervous (CNS), latent infection activation, response to HIV. induced immunosuppression results in emergence opportunistic infections neoplasms that are pathognomonic for acquired immunodeficiency syndrome (AIDS). Infection with also a neurological abnormalities, which has been termed AIDS-dementia complex. Efforts control AIDS require fundamental etiological agent itself, mechanisms by destroys systems, nature against Fortunately, long-standing basic research retroviruses laid groundwork rapid advances accrual immunopathogenic infection. In other retroviral systems persistence unintegrated DNA associated cytopathic effect. infection, substantial amount exists an form, potentially contributing cytopathicity observed The interaction CD4 molecule is present surface helped inducer subset T lymphocytes critical event pathogenesis successful through either therapeutic agents or vaccines requires extensive understanding itself its pathogenesis. fact member lentivirus subfamily viruses was immediate clue natural history would entail lengthy period disease progression, despite generation response.