Influence of aging on catecholamine levels, accumulation, and release in F-344 rats ☆
作者： Helen H. McIntosh , Thomas C. Westfall
DOI: 10.1016/0197-4580(87)90007-8
关键词: Catecholamine 、 Striatum 、 Hypothalamus 、 Cortex (anatomy) 、 Chemistry 、 Internal medicine 、 Midbrain 、 Central nervous system 、 Amphetamine 、 Endocrinology 、 Dopamine
摘要: Neuronal function in selected brain areas has been evaluated Fischer 344 rats aged 2-4 months, 11-14 months and 21-26 months. In vitro release of 3H-norepinephrine from hypothalamus occipital cortex 3H-dopamine striatum using potassium, amphetamine, field-stimulation. uptake 3H-catecholamines the same tissues. Catecholamine levels were measured six areas: hypothalamus, striatum, cortex, cerebellum, brainstem midbrain. Significant age-related decreases NE levels, uptake, to high frequency stimulation seen hypothalamus. The 3H-NE apparent at 12 whereas decrease after was senile rats.
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