Purine metabolism in the bloodstream forms of Trypanosoma gambiense and Trypanosoma rhodesiense.
作者： Wallace R. Fish , Douglas L. Looker , J. Joseph Marr , Randolph L. Berens
DOI: 10.1016/0304-4165(82)90092-7
关键词: Xanthine 、 Nucleotide 、 Biology 、 Purine metabolism 、 Hypoxanthine 、 Inosine 、 Trypanosoma brucei rhodesiense 、 Purine 、 Purine nucleoside phosphorylase 、 Biochemistry
摘要: Bloodstream forms of Trypanosoma brucei gambiense and rhodesiense are incapable de novo purine synthesis. Purine bases converted directly to ribonucleotides with the exception guanine, stable. Guanine is incorporated into also deaminated xanthine. ribonucleosides hydrolyzed rapidly; these reactions may limit their incorporation since label nucleotide pools more efficiently than do ribonucleosides. The apparent order salvage efficiency for adenosine greater inosine guanosine xanthosine both organisms. T. b. salvages in same order, while hypoxanthine adenine guanine
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