SAAG-4 is a novel mosquito salivary protein that programmes host CD4 T cells to express IL-4.

摘要: Mosquitoes represent the most important vector for transmitting pathogens that cause human disease. Central to pathogen transmission is ability divert host immune system away from Th1 and towards Th2 responsiveness. Identification of mosquito factor(s) critical programming responsiveness should therefore lead strategies neutralize their function thus prevent disease transmission. In current study, we used a TCR transgenic adoptive transfer screen gene products present in saliva Aedes aegypti program CD4 T cells express signature cytokine IL-4. The clone SAAG-4 encodes secreted protein with predicted size 20 kDa whose has previously been uncharacterized. Notably, reduced cell expression IFN-γ while simultaneously increasing first identified factor can effector differentiation.