EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
作者： Xiaohua Shen , Yingchun Liu , Yu-Jung Hsu , Yuko Fujiwara , Jonghwan Kim
DOI: 10.1016/J.MOLCEL.2008.10.016
关键词: EZH2 、 Cellular differentiation 、 Molecular biology 、 PRC2 、 Biology 、 Epigenetics 、 Chromatin 、 Histone H3 、 Histone 、 Histone methyltransferase
摘要: Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2) has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the catalytic …
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