Early Detection of Parkinson??s Disease

作者: Rocco Di Paola , Ryan J. Uitti

DOI: 10.2165/00002512-199609030-00002

关键词: Parkinson's diseaseDiseaseEssential tremorNeuroprotectionBioinformaticsExcitotoxicityAmantadinePathologyLevodopaDopaminergicMedicinePharmacology (medical)Geriatrics and Gerontology

摘要: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and characterised by cardinal clinical features specific pathological findings. It possible to detect PD early on in course of disease, certain laboratory studies may identify preclinical stages. Based this information, hypothesis that there a long period, appears be window opportunity influence natural disease. Postulates regarding pathogenesis, such as oxidative stress excitotoxicity, have led discovery abnormal mitochondrial function search for biochemical markers. Functional imaging detected subclinical nigral dopaminergic dysfunction individuals at risk developing PD. Current symptomatic therapies are aimed enhancing transmission. However, some commonly used medications alternative actions with both neuroprotective consequences. Bromocriptine has been postulated antioxidant effects amantadine N-methyl-D-aspartate (NMDA) receptor antagonistic properties. Both reported associated improved survival Additionally, monoamine oxidase type B inhibitors provide neuroprotection. Recent new also under study regard Despite these advances, until better understanding aetiology pathogenesis PD, will no definitive long-term benefit diagnosis treatment

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