Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-Synuclein

摘要: Accumulation of α-synuclein in brain is a hallmark synucleinopathies, neurodegenerative diseases that include Parkinson's disease. Mice overexpressing under the Thy-1 promoter (ASO) show abnormal accumulation cortical and subcortical regions brain, including substantia nigra. We examined motor deficits ASO mice with battery sensorimotor tests are sensitive to alterations nigrostriatal dopaminergic system. Male wild-type were tested every 2 months for 8 performance coordination on challenging beam, inverted grid, pole, an adhesive removal test, spontaneous activity cylinder, gait. Fine skills assessed by ability grasp cotton from bin. displayed significant impairments reduction as early age. Motor became progressively worse age appeared at 6 months. altered 4 worsened These data indicate overexpression induced progressive behavioral phenotype can be detected multiple function. provide useful way assess novel drug therapy genetic models synucleinopathies.