摘要: Ideally, animal models of neurodegenerative diseases should reproduce the clinical manifestation disease and a selective neuronal loss. In this review we will take as an example Parkinson's because its pathophysiology is well known loss characterized. Indeed, characterized by some but not all dopaminergic neurons, non neurons alpha-synuclein positive inclusions resembling Lewy bodies. There are at least two ways to develop PD based on etiology consist in 1) reproducing animals mutations seen inherited forms PD; 2) intoxicating with putative environmental toxins causing PD. discuss advantages drawbacks term neuroproction currently used models.
springer.com
springerlink.com
archives-ouvertes.fr 参考文章(25)
Fiona Thomson, Parkinson's Disease Neuron. ,vol. 39, pp. 889- 909 ,(2003) , 10.1016/S0896-6273(03)00568-3
David D. Song, Clifford W. Shults, Abbyann Sisk, Edward Rockenstein, Eliezer Masliah, Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP111-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Experimental Neurology. ,vol. 186, pp. 158- 172 ,(2004) , 10.1016/S0014-4886(03)00342-X
Ranjita Betarbet, Todd B. Sherer, Gillian MacKenzie, Monica Garcia-Osuna, Alexander V. Panov, J. Timothy Greenamyre, Chronic systemic pesticide exposure reproduces features of Parkinson's disease Nature Neuroscience. ,vol. 3, pp. 1301- 1306 ,(2000) , 10.1038/81834
Pierre Champy, Günter U. Höglinger, Jean Féger, Christophe Gleye, Reynald Hocquemiller, Alain Laurens, Vincent Guérineau, Olivier Laprévote, Fadia Medja, Anne Lombès, Patrick P. Michel, Annie Lannuzel, Etienne C. Hirsch, Merle Ruberg, Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. Journal of Neurochemistry. ,vol. 88, pp. 63- 69 ,(2003) , 10.1046/J.1471-4159.2003.02138.X
Günter U. Höglinger, Jean Féger, Annick Prigent, Patrick P. Michel, Karine Parain, Pierre Champy, Merle Ruberg, Wolfgang H. Oertel, Etienne C. Hirsch, Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats. Journal of Neurochemistry. ,vol. 84, pp. 491- 502 ,(2003) , 10.1046/J.1471-4159.2003.01533.X
Mel B. Feany, Welcome W. Bender, A Drosophila model of Parkinson's disease Nature. ,vol. 404, pp. 394- 398 ,(2000) , 10.1038/35006074
A.J. Herrera, A. Castaño, J.L. Venero, J. Cano, A. Machado, The Single Intranigral Injection of LPS as a New Model for Studying the Selective Effects of Inflammatory Reactions on Dopaminergic System Neurobiology of Disease. ,vol. 7, pp. 429- 447 ,(2000) , 10.1006/NBDI.2000.0289
Sheila M Fleming, Jonathan Salcedo, Pierre-Olivier Fernagut, Edward Rockenstein, Eliezer Masliah, Michael S Levine, Marie-Françoise Chesselet, Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-Synuclein The Journal of Neuroscience. ,vol. 24, pp. 9434- 9440 ,(2004) , 10.1523/JNEUROSCI.3080-04.2004
R. von Coelln, B. Thomas, J. M. Savitt, K. L. Lim, M. Sasaki, E. J. Hess, V. L. Dawson, T. M. Dawson, Loss of locus coeruleus neurons and reduced startle in parkin null mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 10744- 10749 ,(2004) , 10.1073/PNAS.0401297101
Gunter U. Hoglinger, Annie Lannuzel, Myriam Escobar Khondiker, Patrick P. Michel, Charles Duyckaerts, Jean Feger, Pierre Champy, Annick Prigent, Fadia Medja, Anne Lombes, Wolfgang H. Oertel, Merle Ruberg, Etienne C. Hirsch, The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy Journal of Neurochemistry. ,vol. 95, pp. 930- 939 ,(2005) , 10.1111/J.1471-4159.2005.03493.X