Neurotrophic factors as a therapeutic target for Parkinson's disease.
作者： Roger A Barker , Jonathan R Evans
DOI: 10.1517/14728222.12.4.437
关键词:
摘要: Background: The search for therapeutic agents that might alter the disease course in Parkinson's (PD) is ongoing. One area of particular interest involves neurotrophic factors (NTFs), with those glial cell line-derived factor (GDNF) family showing greatest promise. safety and efficacy these therapies has recently come into question. Furthermore, many key questions pertaining to such therapies, as optimal method delivery, timing treatment selection patients most likely benefit, remain unanswered. Objective: In this review we sought evaluate potential NTFs PD. We appraised evidence provided by both vitro vivo work before proceeding a critical assessment relevant clinical trial data. Methods: Relevant literature was identified using PubMed articles published up October 2007. Search terms included: ‘Parkinson's disease’, ‘Neurotrophic factors’, ‘BDNF’ (Brain-deriv...
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