Pharmacokinetics of a single dose of phenytoin in man measured by radioimmunoassay.
作者： JD Robinson , BA Morris , GW Aherne , V Marks
DOI: 10.1111/J.1365-2125.1975.TB02782.X
关键词: Ingestion 、 Radioimmunoassay 、 Internal medicine 、 Endocrinology 、 Normal volunteers 、 Medicine 、 Half-life 、 Pharmacology 、 Pharmacokinetics 、 Phenytoin Sodium 、 Drug 、 Phenytoin
摘要: 1. Serum concentrations of phenytoin were studied by radioimmunoassay in five normal volunteers following a single oral dose sodium (100 mg). 2. Two distinct peaks found at 2.5-3.5 and 10-12 h after ingestion. Maximum serum ranged from 1.56 mug/ml. The mean plasma half-life the drug under these conditions was 9.81 +/- 0.66 (s.e. mean) hours.
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