Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye.

摘要: Using a double labeling indirect immunofluorescent technique, we studied the guinea pig trigeminal ganglion and eye for co-localization of substance P calcitonin gene-related peptide. In ganglion, number neurons immunoreactive peptide significantly outnumber those P, but virtually all positive are eye, complex pattern is present; both peptides co-localize in most nerve fibers. Nerve fibers only tend to be concentrated cornea posterior ciliary body. present relation iris muscles. Sensory denervation by intracranial transection ophthalmic maxillary nerves fails eliminate these CGRP negative These findings indicate an alternative origin supplying muscles this species.