Effect of pituitary adenylate cyclase-activating peptide on isolated rabbit iris sphincter and dilator muscles.
作者： Kazutsuna Yamaji , Yoshitaka Ohnishi , Takeshi Yoshitomi , Hitoshi Ishikawa
DOI:
关键词: Stimulation 、 Phenylephrine 、 Biology 、 Cholinergic 、 Miosis 、 Dilator 、 Endocrinology 、 Pituitary adenylate cyclase-activating peptide 、 Iris dilator muscle 、 Sphincter 、 Internal medicine
摘要: PURPOSE. Pituitary adenylate cyclase-activating peptide (PACAP) is a sensory neuropeptide in the eye that released by noxious stimuli and considered to be mediator of neurogenic ocular injury response, including miosis. The purpose this study was clarify functional role PACAP iris sphincter dilator muscles. METHODS. Iris muscles were isolated from rabbit eyes, effect on mechanical responses these using isometric tension-recording methods investigated. RESULTS. responded electric field stimulation with contractions composed fast twitch subsequent slow components. Both 27 38 enhanced but neither had an response. both PACAPs response dose dependent. Neither amplitude contraction evoked exogenously applied Ach. For muscle, inhibited induced or phenylephrine, whereas no effect. CONCLUSIONS. enhance cholinergic transmission muscle. induces relaxation muscle direct itself. during inflammatory may induce miosis enhancement
arvojournals.org
researchgate.net 参考文章(26)
Karen McConalogue, John B Furness, Melinda A Vremec, Jens J Holst, Karen Tornøe, Philip D Marley, None, Histochemical, pharmacological, biochemical and chromatographic evidence that pituitary adenylyl cyclase activating peptide is involved in inhibitory neurotransmission in the taenia of the guinea-pig caecum Journal of The Autonomic Nervous System. ,vol. 50, pp. 311- 322 ,(1995) , 10.1016/0165-1838(94)00102-P
Tor Elsås, Rolf Uddman, Frank Sundler, Pituitary adenylate cyclase-activating peptide-immunoreactive nerve fibers in the cat eye Graefes Archive for Clinical and Experimental Ophthalmology. ,vol. 234, pp. 573- 580 ,(1996) , 10.1007/BF00448802
Satish Rattan, Sushanta Chakder, Excitatory and Inhibitory Actions of Pituitary Adenylate Cyclase-Activating Peptide (PACAP) in the Internal Anal Sphincter Smooth Muscle: Sites of Actions Journal of Pharmacology and Experimental Therapeutics. ,vol. 283, pp. 722- 728 ,(1997)
Sushanta Chakder, Satish Rattan, Involvement of pituitary adenylate cyclase-activating peptide in opossum internal anal sphincter relaxation American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 275, ,(1998) , 10.1152/AJPGI.1998.275.4.G769
Mochizuki M, Hayashi K, Masuda K, Effects of vasoactive intestinal polypeptide (VIP) and cyclic AMP on isolated dilator pupillae muscle of albino rabbit eye. Japanese Journal of Ophthalmology. ,vol. 27, pp. 647- 654 ,(1983)
Z. K. Krowicki, A. Arimura, N. A. Nathan, P. J. Hornby, Hindbrain effects of PACAP on gastric motor function in the rat. American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 272, ,(1997) , 10.1152/AJPGI.1997.272.5.G1221
Rudolf Kern, [The adrenergic receptors of the intraocular muscles of man. An in vitro-study]. Graefes Archive for Clinical and Experimental Ophthalmology. ,vol. 180, pp. 231- 248 ,(1970) , 10.1007/BF00411532
R A Stone, Y Kuwayama, Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye. Investigative Ophthalmology & Visual Science. ,vol. 28, pp. 1947- 1954 ,(1987)
W E Schmidt, J G Jin, S Katsoulis, J R Grider, Inhibitory transmission in tenia coli mediated by distinct vasoactive intestinal peptide and apamin-sensitive pituitary adenylate cyclase activating peptide receptors. Journal of Pharmacology and Experimental Therapeutics. ,vol. 270, pp. 433- 439 ,(1994)
I Muramatsu, N Ueda, M Fujiwara, Capsaicin and bradykinin-induced substance P-ergic responses in the iris sphincter muscle of the rabbit. Journal of Pharmacology and Experimental Therapeutics. ,vol. 230, pp. 469- 473 ,(1984)